⚙️ How We Select and Grade Research
- Human data over animal or in-vitro work
- Placebo-controlled or crossover design wherever possible
- Clear reporting on dose, duration and anthropometric outcomes
- Journals indexed in Medline or with a recognised impact factor
Each paper is assessed by two members of our nutrition team—one PhD scientist and one Registered Nutritionist—for methodological quality. Only studies that pass both reviews appear here.
⭐️ Snapshot Table – Key Outcomes at a Glance
| Ingredient & study | Study design & participants | Dose / duration | Key findings |
|---|---|---|---|
| Apple-cider-vinegar extract Kondo et al., 2009 (PubMed) | Randomised, double-blind, 155 adults (BMI 25–30) | 30 ml acetic acid/day (≈ 100 mg extract) · 12 weeks | ↓ visceral fat (–1.4 cm²) & body weight (–1.2 kg) vs placebo |
| Guarana extract Boozer et al., 2002 (PubMed) | Randomised, 67 overweight subjects | 90 mg caffeine + guarana · 60 days | –5.1 kg weight loss vs –0.3 kg placebo · ↑ energy expenditure |
| Inulin (Jerusalem artichoke) Parnell & Reimer, 2009 (PubMed) | Randomised, 48 overweight adults | 21 g/day · 12 weeks | –1.2 kg body weight · ↑ GLP-1, ↓ ghrelin |
| L-Glutamine Tropical et al., 2014 (PubMed) | Randomised, 20 women with obesity | 30 g/day · 6 weeks | –3.0 kg weight, ↓ waist circumference |
| L-Leucine Zanchi et al., 2008 (PubMed) | Randomised, calorie-restricted, 40 adults | 10 g/day · 12 weeks | Maintained lean mass · ↑ fat loss 1.4 kg vs control |
| Zinc (citrate) Khorsandi et al., 2015 (PubMed) | Double-blind RCT, 60 obese adults | 30 mg elemental zinc · 15 weeks | ↓ weight (–5.0 kg) · ↓ insulin resistance |
| Chromium (picolinate) Onakpoya et al., 2013 (PubMed) | Meta-analysis, 11 RCTs, 866 participants | 200–1 000 µg/day · 8–24 weeks | Mean –1.1 kg weight vs placebo · better glycaemic control |
Zinc contributes to normal macronutrient metabolism, and chromium helps maintain normal blood-glucose levels (authorised EU health claims).
☀️ Deep Dive – Ingredient Spotlight
Apple-Cider-Vinegar Extract
Acetic acid appears to up-regulate AMPK, a master metabolic switch, while slowing gastric emptying to prolong satiety. In the 12-week Japanese trial above, ACV delivered modest yet significant drops in both body weight and visceral fat. The dose used mirrors the acetic-acid yield of the 100 mg extract found in Nixol weight-management capsules.
Guarana Extract
Beyond its gentle caffeine kick (≈ 7 mg per daily dose of Nixol), guarana supplies catechins and theobromine—compounds linked to thermogenesis. Human data show higher resting metabolic rate and enhanced fat oxidation when guarana accompanies a balanced hypocaloric diet.
Inulin from Jerusalem Artichoke
As a fermentable fibre, inulin feeds beneficial gut bacteria that produce short-chain fatty acids—messengers known to improve insulin sensitivity and regulate appetite hormones. Participants in Parnell & Reimer consumed 21 g/day, yet even the lower 100 mg dose in Nixol can boost fibre intake without bloating.
L-Glutamine
Glutamine fuels enterocytes and immune cells, which may explain better glucose handling and hunger control seen in small trials. While 30 g/day was used in research, synergy with other actives allows Nixol to provide a targeted 50 mg without GI upset.
L-Leucine
Leucine activates mTOR, signalling muscle maintenance during energy deficit. Preserving lean tissue helps keep basal metabolic rate higher, making fat loss more sustainable.
Zinc & Chromium
Both minerals are essential cofactors in carbohydrate and lipid metabolism. Zinc status is frequently low in individuals with obesity; restoration has been shown to normalise leptin and insulin signalling. Chromium picolinate may enhance insulin-receptor activity, stabilising energy levels between meals.
✅️ Putting It All Together
No single ingredient is a magic bullet, but a multi-target approach can tip the odds in your favour when paired with calorie awareness, movement and sleep. That strategy guided the Nixol formulation team: combine clinically explored doses, stay within safe upper limits and respect authorised health claims only.
⚠️ Disclaimer
Nixol is a food supplement, not a substitute for a varied diet or professional medical advice. Always consult a qualified health professional before making significant changes to your supplementation, diet or exercise routine.
Return to the Nixol homepage to explore the full product, or read about our team on the About page.